Samuel’s parentage is just a guess. However, he is in the same area with George Bisher and also comes from Pennsylvania and many of the family names (George, Samuel) appear here.
Margaret is probably too old to be Angeline’s daughter - perhaps a daughter from a previous marriage. Mary appears at the end of the list in the 1850 census (after baby Maranda). She could be a niece or a step-daughter. We don’t know.